Pituitary folliculo-stellate-like cell line produces a cytokine-induced neutrophil chemoattractant

被引:12
作者
Zhang, ZX
Koike, K
Sakamoto, Y
Jikihara, H
Kanda, Y
Inoue, K
Hirota, K
Miyake, A
机构
[1] OSAKA UNIV,SCH MED,DIV OBSTET & GYNECOL,SUITA,OSAKA 565,JAPAN
[2] OSAKA TEISHIN HOSP,DIV OBSTET & GYNECOL,OSAKA,JAPAN
[3] SAITAMA UNIV,FAC SCI,DEPT REG BIOL,CELL BIOL LAB,URAWA,SAITAMA,JAPAN
关键词
D O I
10.1016/S0143-4179(97)90019-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In previous studies, we reported that cytokine-induced neutrophil Chemoattractant (CINC) was produced in the pituitary gland. Here we investigated the possibility of detection of CINC immunoreactivity in the pituitary folliculo-stellate (FS)-like cell line (TtT/GF). Intense immunoreactivity was observed by immunocytochemistry in the cytoplasm and cell processes of TtT/GF cells. CINC immunoreactivity was detected by an enzyme-linked immunosorbent assay in as little as 3 h after conditioning the medium with TtT/GF cells, and it increased significantly in a time-dependent manner during the first 24 h of the culture. This immunoreactivity could be induced by lipopolysaccharide and tumor necrosis factor-alpha in a time- and dose-dependent manner. We also observed the expression of CINC mRNA in TtT/GF cells and LPS increased CINC mRNA accumulation in TtT/GF cells. These findings indicate that CINC produced by FS cells may play a role as a paracrine factor of the anterior pituitary gland, and TtT/GF will provide a useful model system for studying the regulation of CINC secretion by FS cells.
引用
收藏
页码:46 / 51
页数:6
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