Aspirin induced apoptosis in gastric cancer cells

被引：63

作者：

Wong, BCY ^{[1
]}

Zhu, GH ^{[1
]}

Lam, SK ^{[1
]}

机构：

[1] Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1999年 / 53卷 / 07期

关键词：

apoptosis; aspirin; cyclooxygenase; gastric cancer;

D O I：

10.1016/S0753-3322(00)88503-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aspirin has been well known for its anti-pyretic and anti-inflammatory action over the past century. Its main action in the gastro-intestinal tract has always been associated with erosion and ulceration. However in recent years, there has been evidence suggesting that aspirin and the more potent non-steroidal anti-inflammatory drugs (NSAIDs), could reduce the risk of gastric and colon cancer. One of the possible mechanisms in chemo-prevention is the ability to induce apoptosis in epithelial cells of the gastro-intestinal origin. This article introduces the role of apoptosis in the body and the gastro-intestinal tract. Evidence on the chemo-preventive role of aspirin and NSAIDs are listed, and the mechanisms of action discussed. (C) 1999 Elsevier, Paris.

引用

页码：315 / 318

页数：4

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