The TRPC Class of Ion Channels: A Critical Review of Their Roles in Slow, Sustained Increases in Intracellular Ca2+ Concentrations

被引:180
作者
Birnbaumer, Lutz [1 ]
机构
[1] NIEHS, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA
关键词
store operated calcium entry (SOCE); capacitative calcium entry (CCE); calcium release activated calcium current (Icrac); G protein-coupled receptor (GPCR); phospholipase C (PLC); CAPACITATIVE CALCIUM-ENTRY; CA2+-PERMEABLE CATION CHANNEL; RECEPTOR POTENTIAL CHANNELS; DEPENDENT K+ CHANNEL; TRANSIENT-RECEPTOR; 2-AMINOETHOXYDIPHENYL BORATE; FUNCTIONAL-CHARACTERIZATION; MOLECULAR-CLONING; DROSOPHILA TRP; CRAC CHANNEL;
D O I
10.1146/annurev.pharmtox.48.113006.094928
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The realization that there exists a multimembered family of cation channels with structural similarity to Drosophila's Trp channel emerged during the second half of the 1990s. In mammals, depending on the species, the TRP family counts 29 or 30 members which has been subdivided into 6 subfamilies on the basis of sequence similarity. T RP channels are nonselective monovalent cation channels, most of which also allow passage of Ca2+. Many members of each of these families, but not all, are involved in sensory signal transduction. The C-type (for canonical or classical) subfamily, differs front the other TRP subfamilies in that it fulfills two different types of function: membrane depolarization, resembling sensory transduction TRPs, and mediation of sustained increases in intracellular Ca2+. The mechanism(s) by which the C-class of TRP channels-the TRPCs-are activated is poorly understood and their role in mediating intracellular Ca2+ increases is being questioned. Both of these questions-mechanism of activation and participation in Ca2+ entry-are the topics of this review.
引用
收藏
页码:395 / 426
页数:32
相关论文
共 138 条
[1]   From molecule to malady [J].
Ashcroft, FM .
NATURE, 2006, 440 (7083) :440-447
[2]   A comparison of the genes coding for canonical TRP channels and their M, V and P relatives [J].
Birnbaumer, L ;
Yidirim, E ;
Abramowitz, J .
CELL CALCIUM, 2003, 33 (5-6) :419-432
[3]   On the molecular basis and regulation of cellular capacitative calcium entry: Roles for Trp proteins [J].
Birnbaumer, L ;
Zhu, X ;
Jiang, MS ;
Boulay, G ;
Peyton, M ;
Vannier, B ;
Brown, D ;
Platano, D ;
Sadeghi, H ;
Stefani, E ;
Birnbaumer, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (26) :15195-15202
[4]   Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP):: Evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry [J].
Boulay, G ;
Brown, DM ;
Qin, N ;
Jiang, MS ;
Dietrich, A ;
Zhu, MX ;
Chen, ZG ;
Birnbaumer, M ;
Mikoshiba, K ;
Birnbaumer, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :14955-14960
[5]   Cloning and expression of a novel Mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the G(q) class of G protein [J].
Boulay, G ;
Zhu, X ;
Peyton, M ;
Jiang, MS ;
Hurst, R ;
Stefani, E ;
Birnbaumer, L .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (47) :29672-29680
[6]   The capsaicin receptor: a heat-activated ion channel in the pain pathway [J].
Caterina, MJ ;
Schumacher, MA ;
Tominaga, M ;
Rosen, TA ;
Levine, JD ;
Julius, D .
NATURE, 1997, 389 (6653) :816-824
[7]   Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels [J].
Cheng, Kwong Tai ;
Liu, Xibao ;
Ong, Hwei Ling ;
Ambudkar, Indu S. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (19) :12935-12940
[8]   TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes [J].
Chung, MK ;
Lee, H ;
Mizuno, A ;
Suzuki, M ;
Caterina, MJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (20) :21569-21575
[9]   ABNORMAL ELECTRORETINOGRAM FROM A DROSOPHILA MUTANT [J].
COSENS, DJ ;
MANNING, A .
NATURE, 1969, 224 (5216) :285-+
[10]   Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry [J].
DeHaven, Wayne I. ;
Smyth, Jeremy T. ;
Boyles, Rebecca R. ;
Bird, Gary S. ;
Putney, James W., Jr. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (28) :19265-19273