Continuous-Flow Microreactor Chemistry under High-Temperature/Pressure Conditions

被引：133

作者：

Razzaq, Tahseen ^{[1
,2
]}

Glasnov, Toma N. ^{[1
,2
]}

Kappe, C. Oliver ^{[1
,2
]}

机构：

[1] Karl Franzens Univ Graz, CDLMC, A-8010 Graz, Austria

[2] Karl Franzens Univ Graz, Inst Chem, A-8010 Graz, Austria

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 09期

关键词：

Flow chemistry; High-temperature reactions; Microreactors; Process intensification; Supercritical fluids; Microwave chemistry; MICROWAVE SYNTHESIS; COUPLING REACTIONS; ORGANIC-SYNTHESIS; HECK REACTIONS; HIGH-PRESSURE; NEWMAN-KWART; REACTOR; BATCH; TRANSESTERIFICATION; NANOPARTICLES;

D O I：

10.1002/ejoc.200900077

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

High-temperature organic synthesis can be performed under continuous-flow conditions in a stainless steel microtubular flow reactor capable of achieving temperatures of 350 degrees C and 200 bar. Under these extreme experimental environments transformations normally performed in a high-boiling solvent at reflux temperature - or under sedled-vessel microwave conditions - can be readily converted to a flow regime by using lower boiling solvents in or near their supercritical state. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

引用

页码：1321 / 1325

页数：5

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