Estrogen receptor alpha and beta in health and disease

被引：561

作者：

Jia, Min ^{[1
]}

Dahlman-Wright, Karin ^{[1
,2
]}

Gustafsson, Jan-Ake ^{[1
,3
]}

机构：

[1] Karolinska Inst, Dept Biosci & Nutr, S-14183 Huddinge, Sweden

[2] Karolinska Inst, Dept Biosci & Nutr, SciLifeLab, S-17121 Solna, Sweden

[3] Univ Houston, Dept Biol & Biochem, Ctr Nucl Receptors & Cell Signaling, Houston, TX 77204 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2015年 / 29卷 / 04期

关键词：

estrogen receptors; cancer; metabolic disease; BREAST-CANCER CELLS; ER-ALPHA; MESSENGER-RNA; SKELETAL-MUSCLE; TAMOXIFEN RESISTANCE; GLUCOSE-HOMEOSTASIS; PROSTATE-CANCER; GENE-EXPRESSION; ADIPOSE-TISSUE; GENOME-WIDE;

D O I：

10.1016/j.beem.2015.04.008

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Estrogen receptors alpha (ER alpha) and beta (ER beta) are transcription factors that are involved in the regulation of many complex physiological processes in humans. Abnormal ER signaling leads to development of a variety of diseases, such as cancer, metabolic and cardiovascular disease, neurodegeneration, inflammation, and osteoporosis. This review provides an overview and update on ER alpha and ER beta in health and disease with focus on their role in cancer and metabolic disease and in the context of recent years' success in providing genome wide data on ER function. Furthermore, potential clinical applications and challenges are also discussed. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：557 / 568

页数：12

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