Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power

被引：66

作者：

Ferreira, ICFR

Queiroz, MJRP

Vilas-Boas, M

Estevinho, LM

Begouin, A

Kirsch, G

机构：

[1] Inst Politecn Braganca, Escola Super Agraria, P-5301855 Braganca, Portugal

[2] Univ Minho, Dept Quim, P-4710057 Braga, Portugal

[3] Univ Metz 1, Lab Ingn Mol & Biochim Pharmacol, Fac Sci, F-57078 Metz 3, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 05期

关键词：

diarylamines; benzothiophenes; antioxidant activity; structure-activity relationships;

D O I：

10.1016/j.bmcl.2005.11.035

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antioxidant properties of substituted diarylamines in the benzo[b]thiophene series were evaluated by their reducing power and free radical scavenging activity. The results were compared with those of standards: acid ascorbic for the first method and, BHA and BHT for the second. For both methods it was possible to establish some structure-activity relationships (SARs) based on the position of the arylamination on the benzo[b]thiophene moiety, the presence of different substituents on the phenyl ring (F, 1 or 2 OMe) and on the thiophene ring (H, CO2Et, CO2H). (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1384 / 1387

页数：4

共 10 条

[1] Free-radical scavenging capacity and antioxidant activity of selected plant species from the Canadian prairies [J].