Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates

被引:437
作者
Newby, AC [1 ]
机构
[1] Univ Bristol, Bristol Royal Infirm, Bristol Heart Inst, Bristol BS2 8HW, Avon, England
关键词
metalloproteinases; extracellular matrix; focal adhesion kinase; proliferation; migration; apoptosis; cadherins;
D O I
10.1016/j.cardiores.2005.08.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Intimal thickening occurs in blood vessels in response to injury or atherosclerosis. The balance of migration and proliferation of vascular smooth muscle cells (VSMC) over death by apoptosis has an important impact on the final size of intimal thickening and may also affect atherosclerotic plaque stability. All aspects of VSMC behaviour are under coordinated control by growth factors, cell-matrix and cell-cell interactions. We review the evidence that matrix-degrading metalloproteinases (MMPs) regulate migration, proliferation and survival of VSMC. Moreover, we discuss critically the underlying mechanisms, which include changing growth factor availability and remodelling cell-matrix and cell-cell contacts. We conclude that MMPs influence VSMC behaviour by cleaving both matrix and non-matrix substrates. (c) 2005 European Society of Cardiology. Published by Elsevier B.V All rights reserved.
引用
收藏
页码:614 / 624
页数:11
相关论文
共 137 条
[41]   INCREASED EXPRESSION OF MATRIX METALLOPROTEINASES AND MATRIX-DEGRADING ACTIVITY IN VULNERABLE REGIONS OF HUMAN ATHEROSCLEROTIC PLAQUES [J].
GALIS, ZS ;
SUKHOVA, GK ;
LARK, MW ;
LIBBY, P .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (06) :2493-2503
[42]   Matrix metalloproteinases in vascular remodeling and atherogenesis - The good, the bad, and the ugly [J].
Galis, ZS ;
Khatri, JJ .
CIRCULATION RESEARCH, 2002, 90 (03) :251-262
[43]   Progression of atheroma - A struggle between death and procreation [J].
Geng, YH ;
Libby, P .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (09) :1370-1380
[44]   Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima formation in human saphenous veins [J].
George, SJ ;
Baker, AH ;
Angelini, GD ;
Newby, AC .
GENE THERAPY, 1998, 5 (11) :1552-1560
[45]   Surgical preparative injury and neointima formation increase MMP-9 expression and MMP-2 activation in human saphenous vein [J].
George, SJ ;
Zaltsman, AB ;
Newby, AC .
CARDIOVASCULAR RESEARCH, 1997, 33 (02) :447-459
[46]   Inhibition of late vein graft neointima formation in human and porcine models by adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-3 [J].
George, SJ ;
Lloyd, CT ;
Angelini, GD ;
Newby, AC ;
Baker, AH .
CIRCULATION, 2000, 101 (03) :296-304
[47]   Adenovirus-mediated gene transfer of the human TIMP-1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein [J].
George, SJ ;
Johnson, JL ;
Angelini, GD ;
Newby, AC ;
Baker, AH .
HUMAN GENE THERAPY, 1998, 9 (06) :867-877
[48]  
Godin D, 2000, CIRCULATION, V102, P2861
[49]   Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species [J].
Grote, K ;
Flach, I ;
Luchtefeld, M ;
Akin, E ;
Holland, SM ;
Drexler, H ;
Schieffer, B .
CIRCULATION RESEARCH, 2003, 92 (11) :E80-E86
[50]   Tissue inhibitor of metalloproteinases-4 suppresses vascular smooth muscle cell migration and induces cell apoptosis [J].
Guo, YH ;
Gao, W ;
Li, Q ;
Li, PF ;
Yao, PY ;
Chen, KH .
LIFE SCIENCES, 2004, 75 (20) :2483-2493