Memory B cell subpopulations in the aged

被引:51
作者
Colonna-Romano, G
Aquino, A
Bulati, M
Di Lorenzo, G
Listì, F
Vitello, S
Lio, D
Candore, G
Clesi, G
Caruso, C
机构
[1] Univ Palermo, Dipartimento Biopatol & Metodol Biomed, Grp Studio Immunosenescenza, I-90134 Palermo, Italy
[2] Univ Palermo, Dipartimento Med Clin & Patol Emergenti, I-90134 Palermo, Italy
[3] Univ Palermo, Dipartimento Cure Primarie Serv Dipartimentale An, I-90134 Palermo, Italy
[4] Presidio Osped G Di Cristina, ARNAS Osped Civ, Palermo, Italy
关键词
D O I
10.1089/rej.2006.9.149
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The literature on immunosenescence has focused mainly on T cell impairment. With the aim of gaining insight into B cell immunosenescence, the authors investigated the serum IgD levels in 24 young and 21 old people and analyzed their relationship with the number of CD19+CD27+ memory cells. Serum IgD were quantified by the use of radial immunodiffusion and the lymphocyte population CD19+CD27+ was identified by a FACScan flow cytometer. Serum IgD levels were significantly lower (p < 0.0001) in old subjects, and the percentage of CD19+CD27+ lymphocytes were significantly increased (p = 0.01) in old subjects. Finally, a significant negative correlation was found (p = 0.01) between serum concentrations of IgD and CD19+CD27+. The present results show that the levels of IgD are negatively age-related to the amount of B memory cells. This suggests that the B repertoire available to respond to new antigenic challenges is decreased in the elderly. In fact, many memory IgDB cells fill immunologic space, and the number of naive IgD+ B cells is dramatically decreased. Therefore, these preliminary results suggest that a decrease of naive IgD+CD27-B cells and a concomitant increase of memory IgD-CD27+ B cells could represent hallmarks of B immunosenescence, might provide biomarkers related to the lifespan of humans, and could be useful for the evaluation of antiaging treatments.
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页码:149 / 152
页数:4
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