Protective effect of ajoene on acetaminophen-induced hepatic injury in mice

被引：15

作者：

Hattori, A ^{[1
]}

Yamada, N ^{[1
]}

Nishikawa, T ^{[1
]}

Fukuda, H ^{[1
]}

Fujino, T ^{[1
]}

机构：

[1] Nagoya Seiraku Co Ltd, Cent Inst, Biodev Div, Tempaku Ku, Nagoya, Aichi 4680065, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2001年 / 65卷 / 11期

关键词：

acetaminophen; hepatoprotective effect; ajoene; garlic; Allium sativum;

D O I：

10.1271/bbb.65.2555

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ajoene, a garlic-derived sulfur-containing compound, exhibited a hepatoprotective effect against acetaminophen-induced liver injury in mice. A pretreatment with ajoene suppressed the rise in serum glutamic-pyruvic transaminase activity and the reduction in the hepatic reduced glutathione level. These effects of ajoene were observed dose-dependently (20-100 mg/kg). The pretreatment by ajoene also suppressed the decrease in hepatic protein thiol content resulting from acetaminophen administration.

引用

页码：2555 / 2557

页数：3

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