Antimutagenic effects of ajoene, an organosulfur compound derived from garlic

被引：21

作者：

Ishikawa, K ^{[1
]}

Naganawa, R ^{[1
]}

Yoshida, H ^{[1
]}

Iwata, N ^{[1
]}

Fukuda, H ^{[1
]}

Fujino, T ^{[1
]}

Suzuki, A ^{[1
]}

机构：

[1] NAGOYA SEIRAKU CO LTD, CENT INST, BIODEV DIV, TEMPAKU KU, NAGOYA, AICHI 468, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 12期

关键词：

antimutagenic effect; ajoene; garlic; Ames test;

D O I：

10.1271/bbb.60.2086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antimutagenic effects of ajoene, which is an organosulfur compound derived from garlic, were investigated bg the Ames test, Ajoene inhibited mutagenesis induced by both benzo[a]pyrene (B[a]P) and 4-nitro-1,2-phenylenediamine (NPD) in a dose-dependent manner, In particular, NPD-induced mutagenesis was more effectively suppressed by ajoene than the B[a]P-induced type. Furthermore, the inhibition of mutagenesis by ajoene was more effective for transition-type mutations than for the frame shift type. HPLC analysis of B[a]P metabolism in the presence of the rat liver microsomal fraction (S-9) showed that ajoene dose-dependently inhibited the metabolic activation of B[a]P, This suggests that ajoene affected the metabolic enzymes in the S-9 fraction.

引用

页码：2086 / 2088

页数：3

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