Nuclear receptor coregulators: multiple modes of modification

被引:269
作者
Hermanson, O
Glass, CK
Rosenfeld, MG
机构
[1] Univ Calif San Diego, Howard Hughes Med Inst, Dept Med, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S1043-2760(01)00527-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Many proteins have been characterized as coregulators that can be recruited by DNA-binding nuclear receptors to influence transcriptional regulation. Recent genetic and biochemical studies have shown that cellular levels of coregulators are crucial for nuclear receptor-mediated transcription, and many coregulators have been shown to be targets for diverse intracellular signaling pathways and post-translational modifications. This review focuses on the different modes of regulation of nuclear receptor coregulators: and the implications for tissue- and context-specific transcriptional responses to hormone and membrane receptor signaling.
引用
收藏
页码:55 / 60
页数:6
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