Cytokines increase endothelin ETB receptor contractile activity in rat cerebral artery

被引：35

作者：

Leseth, KH

Adner, M

Berg, HK

White, LR

Aasly, J

Edvinsson, L ^{[1
]}

机构：

[1] Univ Trondheim Hosp, Dept Neurol, Trondheim, Norway

[2] Univ Lund Hosp, Dept Internal Med, Div Expt Vasc Res, S-22185 Lund, Sweden

来源：

NEUROREPORT | 1999年 / 10卷 / 11期

关键词：

cerebral arteries; cytokines; endothelin receptors; interleukin-1; interleukin-2; interleukin-6; rat; sarafotoxin S6c; tumor necrosis factor;

D O I：

10.1097/00001756-199908020-00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE plasticity of endothelin ETB receptor activity and the influence of pro-inflammatory cytokines was examined in cerebral artery. In fresh rat basilar artery, the selective ETB receptor agonist, sarafotoxin S6c, induced negligible contractions. However, after 1 day of organ culture, fully defined concentration-response curves were obtained in artery segments exposed to sarafotoxin S6c. Organ culture in the presence of either interleukin-1 beta or tumour necrosis factor-alpha, but not interleukin-2 or interleukin-6, further amplified the maximal contraction to sarafotoxin S6c. The plasticity of ETB recpetor expression in cerebral arteries and sensitivity for pro-inflammatory cytokines, suggest a role in inflammatory cerebral diseases such as stroke. NeuroReport 10:2355-2359 (C) 1999 Lippincott Williams & Wilkins.

引用

页码：2355 / 2359

页数：5

共 25 条

[1] Regional variation in appearance of vascular contractile endothelin-B receptors following organ culture [J].