The type 2 human somatostatin receptor as a platform for reporter gene imaging

被引：54

作者：

Zinn, KR ^{[1
]}

Chaudhuri, TR ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Radiol, Birmingham, AL 35294 USA

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2002年 / 29卷 / 03期

关键词：

imaging gene expression; reporter gene; somatostatin receptor; tumor xenograft; adenovirus;

D O I：

10.1007/s00259-002-0764-y

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The human somatostatin receptor subtype 2A (hSSTr2) is under evaluation as a reporter gene for molecular imaging applications. Two approved somatostatin analogues are already available for imaging expression of the reporter gene following delivery with adenoviral (Ad) vectors or other genetic targeting strategies. In animal models, Ad-mediated expression of hSSTr2 in subcutaneous and intraperitoneal tumors was detected by non-invasive gamma camera imaging. This review discusses the rationale and strategy for using the hSSTr2 reporter gene as a platform for imaging applications.

引用

页码：388 / 399

页数：12

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