The biological cost of antibiotic resistance

被引：654

作者：

Andersson, DI ^{[1
]}

Levin, BR

机构：

[1] Swedish Inst Infect Dis Control, Dept Bacteriol, S-17182 Solna, Sweden

[2] Emory Univ, Dept Biol, Atlanta, GA 30322 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 1999年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1369-5274(99)00005-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The frequency and rates of ascent and dissemination of antibiotic resistance in bacterial populations are anticipated to be directly related to the volume of antibiotic use and inversely related to the cost that resistance imposes on the fitness of bacteria. The data available from recent laboratory studies suggest that most, but not all, resistance-determining mutations and accessory elements engender some fitness cost, but those costs are likely to be ameliorated by subsequent evolution.

引用

页码：489 / 493

页数：5

共 37 条

[1] The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance
Austin, DJ
Kristinsson, KG
Anderson, RM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (03) : 1152 - 1156
[2] Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium
Björkman, J
Samuelsson, P
Andersson, DI
Hughes, D
[J]. MOLECULAR MICROBIOLOGY, 1999, 31 (01) : 53 - 58
[3] Virulence of antibiotic-resistant Salmonella typhimurium
Björkman, J
Hughes, D
Andersson, DI
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) : 3949 - 3953
[4] TUBERCULOSIS - COMMENTARY ON A REEMERGENT KILLER
BLOOM, BR
MURRAY, CJL
[J]. SCIENCE, 1992, 257 (5073) : 1055 - 1064
[5] Resistance of human immunodeficiency virus type 1 to protease inhibitors: Selection of resistance mutations in the presence and absence of the drug
Borman, AM
Paulous, S
Clavel, F
[J]. JOURNAL OF GENERAL VIROLOGY, 1996, 77 : 419 - 426
[6] Fitness of antibiotic-resistant microorganisms and compensatory mutations
Böttger, EC
Springer, B
Pletschette, M
Sander, P
[J]. NATURE MEDICINE, 1998, 4 (12) : 1343 - 1344
[7] EVOLUTION OF A BACTERIA PLASMID ASSOCIATION
BOUMA, JE
LENSKI, RE
[J]. NATURE, 1988, 335 (6188) : 351 - 352
[8] BRYAN LE, 1988, J ANTIMICROB CHEMOTH, V22, P1
[9] EPIDEMIOLOGY OF DRUG-RESISTANCE - IMPLICATIONS FOR A POSTANTIMICROBIAL ERA
COHEN, ML
[J]. SCIENCE, 1992, 257 (5073) : 1050 - 1055
[10] INACTIVATION OF ANTIBIOTICS AND THE DISSEMINATION OF RESISTANCE GENES
DAVIES, J
[J]. SCIENCE, 1994, 264 (5157) : 375 - 382

← 1 2 3 4 →