The biological cost of antibiotic resistance

被引：654

作者：

Andersson, DI ^{[1
]}

Levin, BR

机构：

[1] Swedish Inst Infect Dis Control, Dept Bacteriol, S-17182 Solna, Sweden

[2] Emory Univ, Dept Biol, Atlanta, GA 30322 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 1999年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1369-5274(99)00005-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The frequency and rates of ascent and dissemination of antibiotic resistance in bacterial populations are anticipated to be directly related to the volume of antibiotic use and inversely related to the cost that resistance imposes on the fitness of bacteria. The data available from recent laboratory studies suggest that most, but not all, resistance-determining mutations and accessory elements engender some fitness cost, but those costs are likely to be ameliorated by subsequent evolution.

引用

页码：489 / 493

页数：5

共 37 条

[21] LEVIN BR, 1980, 4 INT S ANT RES, P197
[22] LEVIN BR, 1999, IN PRESS GENETICS
[23] Levy SB., 1992, The Antibiotic Paradox: How Miracle Drugs Are Destroying the Miracle
[24] Horizontal genetic exchange, evolution, and spread of antibiotic resistance in bacteria
Maiden, MCJ
[J]. CLINICAL INFECTIOUS DISEASES, 1998, 27 : S12 - S20
[25] Marshall Neil J., 1997, Microbiologia (Madrid), V13, P285
[26] Epidemiology of emerging/re-emerging antimicrobial-resistant bacterial pathogens
McCormick, JB
[J]. CURRENT OPINION IN MICROBIOLOGY, 1998, 1 (01) : 125 - 129
[27] ADAPTATION OF ESCHERICHIA-COLI GROWTH-RATES TO THE PRESENCE OF PBR322
MCDERMOTT, PJ
GOWLAND, P
GOWLAND, PC
[J]. LETTERS IN APPLIED MICROBIOLOGY, 1993, 17 (03) : 139 - 143
[28] PLASMID MACRO-EVOLUTION - SELECTION OF DELETIONS DURING ADAPTATION IN A NUTRIENT-LIMITED ENVIRONMENT
MODI, RI
WILKE, CM
ROSENZWEIG, RF
ADAMS, J
[J]. GENETICA, 1991, 84 (03) : 195 - 202
[29] MODI RI, 1991, EVOLUTION, V45, P656, DOI 10.1111/j.1558-5646.1991.tb04336.x
[30] ANTIMICROBIAL AGENT RESISTANCE IN MYCOBACTERIA - MOLECULAR-GENETIC INSIGHTS
MUSSER, JM
[J]. CLINICAL MICROBIOLOGY REVIEWS, 1995, 8 (04) : 496 - &

← 1 2 3 4 →