Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity

被引:73
作者
Allen, PB
Zachariou, V
Svenningsson, P
Lepore, AC
Centonze, D
Costa, C
Rossi, S
Bender, G
Chen, G
Feng, J
Snyder, GL
Bernardi, G
Nestler, EJ
Yan, Z
Calabresi, P
Greengard, P
机构
[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06508 USA
[2] Univ Crete, Fac Med, Dept Basic Sci, Iraklion 71003, Crete, Greece
[3] Karolinska Inst, Dept Neurosci, Stockholm, Sweden
[4] Rockefeller Univ, Mol & Cellular Neurosci Lab, New York, NY 10021 USA
[5] Drexel Univ, Coll Med, Dept Neurobiol & Anat, Philadelphia, PA 19129 USA
[6] Univ Roma Tor Vergata, Dept Neurosci, Neurol Clin, Rome, Italy
[7] SUNY Buffalo, Dept Physiol & Biophys, Sch Med & Biomed Sci, Buffalo, NY 14214 USA
[8] Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA
[9] Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dallas, TX 75390 USA
[10] Univ Perugia, Neurol Clin, I-06100 Perugia, Italy
[11] IRCCS, Fdn St Lucia, Rome, Italy
关键词
cytoskeleton; dopamine; dendritic spine; striatum; AMPA receptor; psychostimulant;
D O I
10.1016/j.neuroscience.2006.02.067
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Protein phosphatase 1 plays a major role in the governance of excitatory synaptic activity, and is subject to control via the neuromodulatory actions of dopamine. Mechanisms involved in regulating protein phosphatase 1 activity include interactions with the structurally related cytoskeletal elements spinophilin and neurabin, synaptic scaffolding proteins that are highly enriched in dendritic spines. The requirement for these proteins in dopamine-related neuromodulation was tested using knockout mice. Dopamine D1-mediated regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor activity was deficient in both striatal and prefrontal cortical neurons from neurabin knockout mice; in spinophilin knockout mice this deficit was manifest only in striatal neurons. At corticostriatal synapses long-term potentiation was deficient in neurabin knockout mice, but not in spinophilin knockout mice, and was rescued by a D1 receptor agonist. In contrast, long-term depression was deficient in spinophilin knockout mice but not in neurabin knockout mice, and was rescued by D2 receptor activation. Spontaneous excitatory post-synaptic current frequency was increased in neurabin knockout mice, but not in spinophilin knockout mice, and this effect was normalized by D2 receptor agonist application. Both knockout strains displayed increased induction of GluR1 Ser(815) phosphorylation in response to D1 receptor stimulation in slices, and also displayed enhanced locomotor activation in response to cocaine administration. These effects could be dissociated from cocaine reward, which was enhanced only in spinophilin knockout mice, and was accompanied by increased immediate early gene induction. These data establish a requirement for synaptic scaffolding in dopamine-mediated responses, and further indicate that spinophilin and neurabin play distinct roles in dopaminergic signal transduction and psychostimulant response. (c) 2006 Published by Elsevier Ltd on behalf of IBRO.
引用
收藏
页码:897 / 911
页数:15
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