Nucleic acid enzymes

被引:64
作者
Fiammengo, R [1 ]
Jäschke, A [1 ]
机构
[1] Heidelberg Univ, Inst Pharm & Mol Biotechnol, D-69120 Heidelberg, Germany
关键词
D O I
10.1016/j.copbio.2005.10.006
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Since the discovery of the first natural ribozyme more than 20 years ago, it has become clear that nucleic acids are not only the static depository of genetic information, but also possess intriguing catalytic activity. The number of reactions catalyzed by engineered nucleic acid enzymes is growing continuously. The versatility of these catalysts supports the idea of an ancestral world based on RNA predating the emergence of proteins, and also drives many studies towards practical applications for nucleic acid enzymes.
引用
收藏
页码:614 / 621
页数:8
相关论文
共 56 条
[1]   Ribozymes in the age of molecular therapeutics [J].
Bagheri, S ;
Kashani-Sabet, M .
CURRENT MOLECULAR MEDICINE, 2004, 4 (05) :489-506
[2]   From peptide-bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects [J].
Baram, D ;
Yonath, A .
FEBS LETTERS, 2005, 579 (04) :948-954
[3]   Target-dependent on/off switch increases ribozyme fidelity [J].
Bergeron, LJ ;
Perreault, JP .
NUCLEIC ACIDS RESEARCH, 2005, 33 (04) :1240-1248
[4]   A common speed limit for RNA-cleaving ribozymes and deoxyribozymes [J].
Breaker, RR ;
Emilsson, GM ;
Lazarev, D ;
Nakamura, S ;
Puskarz, IJ ;
Roth, A ;
Sudarsan, N .
RNA, 2003, 9 (08) :949-957
[5]   Immobilised enzymes: carrier-bound or carrier-free? [J].
Cao, LQ ;
van Langen, L ;
Sheldon, RA .
CURRENT OPINION IN BIOTECHNOLOGY, 2003, 14 (04) :387-394
[6]   Combinatorial minimization and secondary structure determination of a nucleotide synthase ribozyme [J].
Chapple, KE ;
Bartel, DP ;
Unrau, PJ .
RNA, 2003, 9 (10) :1208-1220
[7]   An autonomous DNA nanomotor powered by a DNA enzyme [J].
Chen, Y ;
Wang, MS ;
Mao, CD .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (27) :3554-3557
[8]   Rational modification of a selection strategy leads to deoxyribozymes that create native 3′-5′ RNA linkages [J].
Coppins, RL ;
Silverman, SK .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (50) :16426-16432
[9]   Dinucleotide junction cleavage versatility of 8-17 deoxyribozyme [J].
Cruz, RPG ;
Withers, JB ;
Li, YF .
CHEMISTRY & BIOLOGY, 2004, 11 (01) :57-67
[10]   Deoxyribozymes: cleaving a path to clinical trials [J].
Dass, CR .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2004, 25 (08) :395-397