Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1

被引：11

作者：

Cheung, M. ^{[1
]}

Kuntz, K. W. ^{[1
]}

Pobanz, M. ^{[1
]}

Salovich, J. M. ^{[1
]}

Wilson, B. J. ^{[1
]}

Andrews, C. W., III ^{[1
]}

Shewchuk, L. M. ^{[1
]}

Epperly, A. H. ^{[1
]}

Hassler, D. F. ^{[1
]}

Leesnitzer, M. A. ^{[1
]}

Smith, J. L. ^{[1
]}

Smith, G. K. ^{[1
]}

Lansing, T. J. ^{[1
]}

Mook, R. A., Jr. ^{[1
]}

机构：

[1] GlaxoSmithKline, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 23期

关键词：

Imidazotriazine; Polo-like kinase inhibitor;

D O I：

10.1016/j.bmcl.2008.09.100

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The synthesis and biological activities of imidazo[5,1-f][1,2,4] triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported. (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：6214 / 6217

页数：4

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