Sequence-specific cleavage of yeast tRNA(Phe) with oligonucleotides conjugated to a diimidazole construct

被引：44

作者：

Vlassov, V ^{[1
]}

Abramova, T ^{[1
]}

Godovikova, T ^{[1
]}

Giege, R ^{[1
]}

Silnikov, V ^{[1
]}

机构：

[1] CNRS,INST BIOL MOL & CELLULAIRE,UNITE PROPRE RECH 9002 STRUCT MACROMOL BIOL & MEC,F-67084 STRASBOURG,FRANCE

来源：

ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1089/oli.1.1997.7.39

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oligonucleotide derivatives conjugated to a chemical construction,vith two histamine residues imitating the catalytic center of ribonuclease A have been synthesized. In experiments with the conjugates complementary to the 3'-end and to the variable loop and the T loop of yeast tRNA(Phe), if was shown that the compounds can accomplish sequence-specific cleavage of the target RNA in physiologic conditions.

引用

页码：39 / 42

页数：4

共 15 条

[1] SEQUENCE-SPECIFIC CLEAVAGE OF HIV MESSENGER-RNA BY A RIBOZYME MIMIC [J].