A Born-type approximation method for bioluminescence tomography

被引：44

作者：

Cong, WX ^{[1
]}

Durairaj, K

Wang, LV

Wang, G

机构：

[1] Univ Iowa, Dept Radiol, Bioluminescence Tomog Lab, Iowa City, IA 52242 USA

[2] Texas A&M Univ, Opt Imaging Lab, Dept Biomed Engn, College Stn, TX 77843 USA

来源：

MEDICAL PHYSICS | 2006年 / 33卷 / 03期

关键词：

bioluminescence tomography (BLT); diffusion approximation; Green function; Born approximation;

D O I：

10.1118/1.2168293

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In this paper, we present a Born-type approximation method for bioluminescence tomography (BLT), which is to reconstruct an internal bioluminescent source from the measured bioluminescent signal on the external surface of a small animal. Based on the diffusion approximation for the photon propagation in biological tissue, this BLT method utilizes the Green function to establish a linear relationship between the measured bioluminescent signal and the internal bioluminescent source distribution. The Green function can be modified to describe a heterogeneous medium with an arbitrary boundary using the Born approximation. The BLT reconstruction is formulated in a linear least-squares optimization framework with simple bounds constraint. The performance of this method is evaluated in numerical simulation and phantom experiments. (c) 2006 American Association of Physicists in Medicine.

引用

页码：679 / 686

页数：8

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