ESCRTs and human disease

被引：81

作者：

Saksena, Suraj

Emr, Scott D. ^{[1
]}

机构：

[1] Cornell Univ, Weill Inst Cell & Mol Biol, Ithaca, NY 14853 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2009年 / 37卷

关键词：

cancer; endosomal sorting complex required for transport (ESCRT); endosome; multivesicular body (MVB); neurodegeneration; pathogenesis; GROWTH-FACTOR; CELL-CYCLE; PROTEIN; DROSOPHILA; COMPLEX; SUSCEPTIBILITY; MUTATIONS; TSG101; NOTCH; GENE;

D O I：

10.1042/BST0370167

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ESCRT (endosomal sorting complex required for transport) machinery plays a critical role in receptor down-regulation, retroviral budding, and other normal and pathological processes. The ESCRT components are conserved in all five major subgroups of eukaryotes. This review summarizes the growing number of links identified between ESCRT-mediated protein sorting in the MVB (multivesicular body) pathway and various human diseases.

引用

收藏

页码：167 / 172

页数：6

相关论文

共 50 条

[1] Defective downregulation of receptor tyrosine kinases in cancer [J].

Bache, KG ;

Slagsvold, T ;

Stenmark, H .

EMBO JOURNAL, 2004, 23 (14) :2707-2712

[2] The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor [J].

Bache, Kristi G. ;

Stuffers, Susanne ;

Malerod, Lene ;

Slagsvold, Thomas ;

Raiborg, Camilla ;

Lechardeur, Delphine ;

Walchli, Sebastien ;

Lukacs, Gergely L. ;

Brech, Andreas ;

Stenmark, Harald .

MOLECULAR BIOLOGY OF THE CELL, 2006, 17 (06) :2513-2523

[3] Oncogenic kinase signalling [J].

Blume-Jensen, P ;

Hunter, T .

NATURE, 2001, 411 (6835) :355-365

[4] LIDDLES SYNDROME REVISITED - A DISORDER OF SODIUM-REABSORPTION IN THE DISTAL TUBULE [J].

BOTEROVELEZ, M ;

CURTIS, JJ ;

WARNOCK, DG .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (03) :178-181

[5] Parallels between cytokinesis and retroviral budding: A role for the ESCRT machinery [J].

Carlton, Jez G. ;

Martin-Serrano, Juan .

SCIENCE, 2007, 316 (5833) :1908-1912

[6] Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells [J].

Carstens, MJ ;

Krempler, A ;

Triplett, AA ;

van Lohuizen, M ;

Wagner, KU .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (34) :35984-35994

[7] Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1 [J].

Chang, SS ;

Grunder, S ;

Hanukoglu, A ;

Rosler, A ;

Mathew, PM ;

Hanukoglu, I ;

Schild, L ;

Lu, Y ;

Shimkets, RA ;

NelsonWilliams, C ;

Rossier, BC ;

Lifton, RP .

NATURE GENETICS, 1996, 12 (03) :248-253

[8] Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye [J].

Chao, JL ;

Tsai, YC ;

Chiu, SJ ;

Sun, YH .

DEVELOPMENT, 2004, 131 (16) :3839-3847

[9] Retrovirus budding [J].

Demirov, DG ;

Freed, EO .

VIRUS RESEARCH, 2004, 106 (02) :87-102

[10] Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease [J].

Filimonenko, Maria ;

Stuffers, Susanne ;

Raiborg, Camilla ;

Yamamoto, Ai ;

Malerod, Lene ;

Fisher, Elizabeth M. C. ;

Isaacs, Adrian ;

Brech, Andreas ;

Stenmark, Harald ;

Simonsen, Anne .

JOURNAL OF CELL BIOLOGY, 2007, 179 (03) :485-500

← 1 2 3 4 5 →