ESCRTs and human disease

被引：81

作者：

Saksena, Suraj

Emr, Scott D. ^{[1
]}

机构：

[1] Cornell Univ, Weill Inst Cell & Mol Biol, Ithaca, NY 14853 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2009年 / 37卷

关键词：

cancer; endosomal sorting complex required for transport (ESCRT); endosome; multivesicular body (MVB); neurodegeneration; pathogenesis; GROWTH-FACTOR; CELL-CYCLE; PROTEIN; DROSOPHILA; COMPLEX; SUSCEPTIBILITY; MUTATIONS; TSG101; NOTCH; GENE;

D O I：

10.1042/BST0370167

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ESCRT (endosomal sorting complex required for transport) machinery plays a critical role in receptor down-regulation, retroviral budding, and other normal and pathological processes. The ESCRT components are conserved in all five major subgroups of eukaryotes. This review summarizes the growing number of links identified between ESCRT-mediated protein sorting in the MVB (multivesicular body) pathway and various human diseases.

引用

收藏

页码：167 / 172

页数：6

相关论文

共 50 条

[21] tsg101: A novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells [J].

Li, LM ;

Cohen, SN .

CELL, 1996, 85 (03) :319-329

[22] A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control [J].

Li, LM ;

Liao, J ;

Ruland, J ;

Mak, TW ;

Cohen, SN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (04) :1619-1624

[23] Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila [J].

Lloyd, TE ;

Atkinson, R ;

Wu, MN ;

Zhou, Y ;

Pennetta, G ;

Bellen, HJ .

CELL, 2002, 108 (02) :261-269

[24] Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation [J].

Malerod, Lene ;

Stuffers, Susanne ;

Brech, Andreas ;

Stenmark, Harald .

TRAFFIC, 2007, 8 (11) :1617-1629

[25] Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth [J].

Moberg, KH ;

Schelble, S ;

Burdick, SK ;

Hariharan, IK .

DEVELOPMENTAL CELL, 2005, 9 (05) :699-710

[26] Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis [J].

Morita, Eiji ;

Sandrin, Virginie ;

Chung, Hyo-Young ;

Morham, Scott G. ;

Gygi, Steven P. ;

Rodesch, Christopher K. ;

Sundquist, Wesley I. .

EMBO JOURNAL, 2007, 26 (19) :4215-4227

[27] Frontotemporal dementia [J].

Neary, D ;

Snowden, J ;

Mann, D .

LANCET NEUROLOGY, 2005, 4 (11) :771-780

[28] SH2 domains, interaction modules and cellular wiring [J].

Pawson, T ;

Gish, GD ;

Nash, P .

TRENDS IN CELL BIOLOGY, 2001, 11 (12) :504-511

[29] Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein [J].

Peschard, P ;

Fournier, TM ;

Lamorte, L ;

Naujokas, MA ;

Band, H ;

Langdon, WY ;

Park, M .

MOLECULAR CELL, 2001, 8 (05) :995-1004

[30] ESCRT factors restrict mycobacterial growth [J].

Philips, Jennifer A. ;

Porto, Maura C. ;

Wang, Hui ;

Rubint, Eric J. ;

Perrimont, Norbert .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (08) :3070-3075

← 1 2 3 4 5 →