A New Role for E2F-1 in Checkpoint Control

被引：30

作者：

Stevens, Craig ^{[1
]}

La Thangue, Nicholas B. ^{[1
]}

机构：

[1] Univ Glasgow, Div Biochem & Mol Biol, Davidson Bldg, Glasgow G12 8QQ, Lanark, Scotland

来源：

CELL CYCLE | 2003年 / 2卷 / 05期

基金：

英国医学研究理事会;

关键词：

E2F-1; Chk2; DNA damage; checkpoint; apoptosis; cancer;

D O I：

10.4161/cc.2.5.462

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In response to DNA damage, E2F-1 is induced and phosphorylated. Phosphorylated E2F-1 can reside in discrete nuclear structures and induce apoptosis, suggesting a unique role for E2F-1 in DNA repair and checkpoint functions.

引用

页码：435 / 437

页数：3

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