Angiogenesis in lymphoproliferative disorders

被引：17

作者：

Salven, P ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Div Hematol Oncol, New York, NY 10021 USA

来源：

ACTA HAEMATOLOGICA | 2001年 / 106卷 / 04期

关键词：

angiogenesis; fibroblast growth factor; basic; leukemia; lymphoma; lymphoproliferative disorders; malignancies; hematological; multiple myeloma; vascular endothelial growth factor;

D O I：

10.1159/000046615

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this review, the cellular and molecular mechanisms underlying angiogenesis in lymphoproliferative disorders are summarized, alongside with possible therapeutic applications. Although most of the initial studies in angiogenesis were done on solid tumors, recent data demonstrate the importance of angiogenesis in hematological malignancies including leukemia, lymphoma, and multiple myeloma. Expression of angiogenic polypeptides vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) correlate with clinical characteristics in leukemia and lymphoma, and their serum concentrations serve as predictors of poor prognosis. Antiangiogenic drugs, including thalidomide, arsenic trioxide, endostatin, vasostatin, and neutralizing antibodies to VEGF receptors, used alone or in combination with established chemo- or immunotherapy regimens, constitute a promising approach for the treatment of lymphoproliferative disorders. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：184 / 189

页数：6

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