Signaling mechanisms for activation of extracytoplasmic function (ECF) sigma factors

被引:70
作者
Brooks, Benjamin E. [1 ]
Buchanan, Susan K. [1 ]
机构
[1] NIDDKD, NIH, Mol Biol Lab, Bethesda, MD 20892 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2008年 / 1778卷 / 09期
关键词
ECF; sigma factor; anti-sigma factor; sigma E; Fecl;
D O I
10.1016/j.bbamem.2007.06.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A variety of mechanisms are used to signal extracytoplasmic conditions to the cytoplasm. These mechanisms activate extracytoplasmic function (ECF) sigma factors which recruit RNA-polymerase to specific genes in order to express appropriate proteins in response to the changing environment. The two best understood ECF signaling pathways regulate sigma(E)-mediated expression of periplasmic stress response genes in Escherichia coli and Fecl-mediated expression of iron-citrate transport genes in E. coli. Homologues from other Gram-negative bacteria suggest that these two signaling mechanisms and variations on these mechanisms may be the general schemes by which ECF sigma factors are regulated in Gram-negative bacteria. Published by Elsevier B.V.
引用
收藏
页码:1930 / 1945
页数:16
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