Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates

被引：38

作者：

Tamura, SY

Semple, JE

Reiner, JE

Goldman, EA

Brunck, TK

LimWilby, MS

Carpenter, SH

Rote, WE

Oldeshulte, GL

Richard, BM

Nutt, RF

Ripka, WC

机构：

[1] Department of Medicinal Chemistry, Corvas International, Inc., San Diego, CA 92121

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(97)00258-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several potent and selective inhibitors of thrombin incorporating novel heterocyclic peptide surrogates in the P-3-P-2 position of peptidyl argininals have been discovered. Illustrated in this article are three classes of heterocycles: pyridones, uracils, and pyrimidinones. The synthesis and biological activities of these unique aromatic heterocyclic derivatives are reported herein. (C) 1997 Elsevier Science Ltd.

引用

页码：1543 / 1548

页数：6

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