Changes in perfusion and diffusion in the endplate regions of degenerating intervertebral discs: a DCE-MRI study

被引：28

作者：

Arpinar, Volkan Emre ^{[1
]}

Rand, Scott D. ^{[3
]}

Klein, Andrew P. ^{[3
]}

Maiman, Dennis J. ^{[1
]}

Muftuler, L. Tugan ^{[1
,2
]}

机构：

[1] Med Coll Wisconsin, Froedtert Hosp, Dept Neurosurg, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Ctr Imaging Res, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Dept Radiol, Milwaukee, WI 53226 USA

来源：

EUROPEAN SPINE JOURNAL | 2015年 / 24卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Dynamic contrast-enhanced magnetic resonance imaging; Intervertebral disc endplate; Intervertebral disc degeneration; Lumbar spine; HUMAN LUMBAR DISCS; MORPHOLOGY; TRANSPORT; CALCIFICATION; VIABILITY; FLOW;

D O I：

10.1007/s00586-015-4172-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Dynamic contrast-enhanced MRI (DCE-MRI) was used to investigate the associations between intervertebral disc degeneration and changes in perfusion and diffusion in the disc endplates. 56 participants underwent MRI scans. Changes in DCE-MRI signal enhancement in the endplate regions were analyzed. Also, a group template was generated for the endplates and enhancement maps were registered to this template for group analysis. DCE-MRI enhancement changed significantly in cranial endplates with increased degeneration. A similar trend was observed for caudal endplates, but it was not significant. Group-averaged enhancement maps revealed major changes in spatial distribution of endplate perfusion and diffusion with increasing disc degeneration especially in peripheral endplate regions. Increased enhancement in the endplate regions of degenerating discs might be an indication of ongoing damage in these tissues. Therefore, DCE-MRI could aid in understanding the pathophysiology of disc degeneration. Moreover, it could be used in the planning of novel treatments such as stem cell therapy.

引用

页码：2458 / 2467

页数：10

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