Synthesis of 5-(bromomethylene)furan-2(5H)-ones and 3-(bromomethylene)isobenzofuran-1(3H)-ones as inhibitors of microbial quorum sensing

被引：29

作者：

Benneche, Tore ^{[1
]}

Hussain, Zainab ^{[1
]}

Scheie, Anne Aamdal ^{[2
]}

Lonn-Stensrud, Jessica ^{[2
]}

机构：

[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

[2] Univ Oslo, Fac Dent, Dept Oral Biol, N-0315 Oslo, Norway

来源：

NEW JOURNAL OF CHEMISTRY | 2008年 / 32卷 / 09期

关键词：

D O I：

10.1039/b803926g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(E)- and (Z)-5-(Bromomethylene)furan-2(5H)-ones and (E)- and (Z)-3-(bromomethylene)isobenzofuran-1(3H)-ones have been prepared starting from commercially available maleic anhydrides and phthalic anhydrides, respectively. A debrominative decarboxylation or a bromodecarboxylation reaction is a key step in the synthesis. The furanones were investigated for their ability to interfere with microbial communication and biofilm formation by Staphylococcus epidermidis.

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页码：1567 / 1572

页数：6

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