Antiphospholipid (Hughes') syndrome in African-Americans:: IgA aCL and αβ2 glycoprotein-I is the most frequent isotype

被引：53

作者：

Diri, E ^{[1
]}

Cucurull, E ^{[1
]}

Gharavi, AE ^{[1
]}

Kapoor, D ^{[1
]}

Mendez, EA ^{[1
]}

Scopelitis, E ^{[1
]}

Wilson, WA ^{[1
]}

机构：

[1] Louisiana State Univ, Med Ctr, Dept Med, Rheumatol Sect, New Orleans, LA 70112 USA

来源：

LUPUS | 1999年 / 8卷 / 04期

关键词：

anticardiolipin antibodies; anti-beta(2)glycoprotein-I antibodies; antiphospholipid syndrome; African-Americans;

D O I：

10.1191/096120399678847812

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antiphospholipid (Hughes') syndrome (APS) has not been reported in African-Americans (A-A) as frequently as in other ethnic groups. We describe eight A-A female patients with APS, including two cases of primary APS (PAPS), four with APS secondary to systemic lupus erythematosus (SLE), one with Sjogren's syndrome, and one with overlap connective tissue disease (CTD). Their mean age was 34 y (range 24-47 y). Patients were followed for a mean of 6 y (range 0.3-11 y). During follow up, both anticardiolipin (aCL) and anti-/beta(2)glycoplotein-1 (a beta(2)GPI) antibodies were measured in stored sera by enzyme-linked immunosorbent assay (ELISA). IgA was the most frequent isotype of aCL and a beta(2)GPI, and co-occurred with the IBM isotype in three of four patients with neurologic manifestations.

引用

页码：263 / 268

页数：6

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