New lupane glycosides from Pulsatilla chinensis

被引：78

作者：

Ye, WC

Zhang, QW

Hsiao, WWL

Zhao, SX

Che, CT ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Sch Chinese Med, Shatin, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[3] China Pharmaceut Univ, Dept Phytochem, Nanjing, Peoples R China

[4] Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China

来源：

PLANTA MEDICA | 2002年 / 68卷 / 02期

关键词：

D O I：

10.1055/s-2002-20254

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Two new lupane glycosides along with five known triterpenoids were isolated from the roots of Pulsatilla chinensis (Ranunculaceae). The structures of the new glycosides were determined to be 3-O-beta-D-glucopyranosyl(1-->3)-alpha-L-arabinopyranosyl-23-hydroxybetulinic acid 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranosyl ester (pulsatilloside D, 6) and 3-O-[beta-D-glucopyranosyl(1-->4)][alpha-L-rhamnopyranosyl(1-->2)]-alpha-L-arabinopyranosyl-23-hydroxybetulinic acid 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranosyl ester (pulsatilloside E, 7) by spectroscopic analysis and chemical methods. The compounds were evaluated for cytotoxic activities against K-562 human leukemia and HeLa cells.

引用

页码：183 / 186

页数：4

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