Substituted phenanthrenes with basic amino side chains: A new series of anti-breast cancer agents

被引：107

作者：

Shagufta

Srivastava, AK

Sharma, R

Mishra, R

Balapure, AK

Murthy, PSR

Panda, G ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, NLAC, Tissue Culture Lab, Lucknow 226001, Uttar Pradesh, India

[3] Cent Drug Res Inst, Div Toxicol, Carcinogen Unit, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 05期

关键词：

substituted phenanthrenes; anti-breast cancer agents; basic amino side chain;

D O I：

10.1016/j.bmc.2005.10.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the course of our search for new anti-breast cancer agents, substituted phenanthrenes with basic amino side chains were synthesized and some of them showed remarkable antiproliferative activity against ER +ve MCF-7 cell line with IC50 in the range of 3.53-22.25 mu M. One of the compounds 15ca showed anti-breast cancer activity in 7,12-dimethylbenz[a]anthracene (DMBA) induced hormone-dependent mammary tumor in rat and the activity was comparable to that shown by tamoxifen. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：1497 / 1505

页数：9

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