Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults

被引:74
作者
Giustina, A. [1 ]
Barkan, A. [2 ]
Chanson, P. [3 ,4 ,5 ]
Grossman, A. [6 ]
Hoffman, A. [7 ]
Ghigo, E. [8 ]
Casanueva, F. [9 ,10 ]
Colao, A. [11 ]
Lamberts, S. [12 ]
Sheppard, M. [13 ]
Melmed, S. [14 ]
机构
[1] Univ Brescia, Dept Internal Med, Brescia, Italy
[2] Univ Michigan, Med Ctr, Div Endocrinol & Metab, Ann Arbor, MI USA
[3] Bicetre Hosp, Dept Endocrinol, Le Kremlin Bicetre, France
[4] Bicetre Hosp, Dept Reprod Dis, Le Kremlin Bicetre, France
[5] Univ Paris 11, Le Kremlin Bicetre, France
[6] Queen Mary Univ, Barts & London Sch Med, St Bartholomews Hosp, Dept Endocrinol, London, England
[7] Stanford Univ, Dept Endocrinol Gerontol & Metab, Stanford, CA 94305 USA
[8] Univ Turin, Dept Internal Med, Div Endocrinol, Turin, Italy
[9] Dept Med, Div Endocrinol, Santiago De Compostela, Spain
[10] Complejo Hosp Santiago, Santiago De Compostela, Spain
[11] Univ Naples Federico II, Dept Mol & Clin Endocrinol & Oncol, Naples, Italy
[12] Erasmus MC, Dept Med, Rotterdam, Netherlands
[13] Univ Birmingham Edgbaston, Sch Med, Birmingham, W Midlands, England
[14] Cedars Sinai Med Ctr, Dept Endocrinol, Los Angeles, CA 90048 USA
关键词
Acromegaly; growth hormone deficiency; growth hormone replacement; somatostatin analogs; treatment recommendations;
D O I
10.1007/BF03349263
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The V Consensus Group Meeting on 'Guidelines for Treatment of GH Excess and GH Deficiency in the Adult' was an international workshop held on February 20-22, 2006 in Santa Monica, California, USA. The principal aim of this meeting was to provide guidelines for the evaluation and treatment of adults with either form of abnormal GH secretion: GH excess or GH deficiency. The workshop included debates as to the choice of primary treatment, discussions of the targets for adequate treatment, and concluded with presentations on open issues germane to adult GH treatment including the role of GH in malignancies, the impact of long-term treatment on bone, and a cost-benefit analysis. The meeting was comprised of 66 delegates representing 13 different countries.
引用
收藏
页码:820 / 838
页数:19
相关论文
共 173 条
[71]   Evaluation of disease status with sensitive measures of growth hormone secretion in 60 postoperative patients with acromegaly [J].
Freda, PU ;
Post, KD ;
Powell, JS ;
Wardlaw, SL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (11) :3808-3816
[72]   Long-term endocrinological follow-up evaluation in 115 patients who underwent transsphenoidal surgery for acromegaly [J].
Freda, PU ;
Wardlaw, SL ;
Post, K .
JOURNAL OF NEUROSURGERY, 1998, 89 (03) :353-358
[73]  
Gharib Hossein, 2003, Endocr Pract, V9, P64
[74]   New approach to the diagnosis of growth hormone deficiency in adults [J].
Ghigo, E ;
Aimaretti, G ;
Gianotti, L ;
Bellone, J ;
Arvat, E ;
Camanni, F .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1996, 134 (03) :352-356
[75]   Effect of recombinant human growth hormone (GH) replacement on the hypothalamic-pituitary-adrenal axis in adult GH-deficient patients [J].
Giavoli, C ;
Libé, R ;
Corbetta, S ;
Ferrante, E ;
Lania, A ;
Arosio, M ;
Spada, A ;
Beck-Peccoz, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (11) :5397-5401
[76]   Outcome of surgery for acromegaly - the experience of a dedicated pituitary surgeon [J].
Gittoes, NJL ;
Sheppard, MC ;
Johnson, AP ;
Stewart, PM .
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS, 1999, 92 (12) :741-745
[77]   Criteria for cure of acromegaly: A consensus statement [J].
Giustina, A ;
Barkan, A ;
Casanueva, FF ;
Cavagnini, F ;
Frohman, L ;
Ho, K ;
Veldhuis, J ;
Wass, J ;
Von Werder, K ;
Melmed, S .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (02) :526-529
[78]   Diagnosis and treatment of acromegaly complications [J].
Giustina, A ;
Casanueva, FF ;
Cavagnini, F ;
Chanson, P ;
Clemmons, D ;
Frohman, LA ;
Gaillard, R ;
Ho, K ;
Jaquet, P ;
Kleinberg, DL ;
Lamberts, SWJ ;
Lombardi, G ;
Sheppard, M ;
Strasburger, CJ ;
Vance, ML ;
Wass, JAH ;
Melmed, S .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2003, 26 (12) :1242-1247
[79]   Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human [J].
Giustina, A ;
Veldhuis, JD .
ENDOCRINE REVIEWS, 1998, 19 (06) :717-797
[80]   Resistance to somatostatin analogs in acromegaly: An evolving concept? [J].
Gola, M ;
Bonadonna, S ;
Mazziotti, G ;
Amato, G ;
Giustina, A .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2006, 29 (01) :86-93