Linking calcium to Aβ and Alzheimer's disease

被引：272

作者：

Green, Kim N. ^{[1
,2
]}

LaFerla, Frank M. ^{[1
,2
]}

机构：

[1] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA

来源：

NEURON | 2008年 / 59卷 / 02期

关键词：

D O I：

10.1016/j.neuron.2008.07.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent developments point to a critical role for calcium dysregulation in the pathogenesis of Alzheimer's disease. A novel calcium-conducting channel called CALHM1 is genetically linked to the disorder and modulates A beta production. Calcium homeostasis has also been shown to be perturbed in dendritic spines adjacent to amyloid plaques. Finally, new studies have elucidated the role by which presenilins modulate calcium signaling, including effects on SERCA2b and gating of the IP(3) receptor, and lead to A beta production.

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收藏

页码：190 / 194

页数：5

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