IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8+ T cell responses to influenza A virus

被引：111

作者：

Pang, Iris K. ^{[1
]}

Ichinohe, Takeshi ^{[1
]}

Iwasaki, Akiko ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 03期

基金：

美国国家卫生研究院;

关键词：

SINGLE-STRANDED RNA; ANTIGEN PRESENTATION; ANTIVIRAL RESPONSES; ADAPTIVE IMMUNITY; ACTIVATION; INTERLEUKIN-1; INNATE; POPULATIONS; INDUCTION; INFECTION;

D O I：

10.1038/ni.2514

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune responses to vaccines require direct recognition of pathogen-associated molecular patterns (PAMPs) through pattern-recognition receptors (PRRs) on dendritic cells (DCs). Unlike vaccination, infection by a live pathogen often impairs DC function and inflicts additional damage on the host. Here we found that after infection with live influenza A virus, signaling through the interleukin 1 receptor (IL-1R) was required for productive priming of CD8(+) T cells, but signaling through the PRRs TLR7 and RIG-I was not. DCs activated by IL-1 in trans were both required and sufficient for the generation of virus-specific CD8(+) T cell immunity. Our data demonstrate a critical role for a bystander cytokine in the priming of CD8(+) T cells during infection with a live virus.

引用

页码：246 / 253

页数：8

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