Rat macrophages:: membrane glycoproteins in differentiation and function

被引：34

作者：

van den Berg, TK ^{[1
]}

Döpp, EA ^{[1
]}

Dijkstra, CD ^{[1
]}

机构：

[1] VU Med Ctr, Dept Mol Cell Biol, NL-1081 BT Amsterdam, Netherlands

来源：

IMMUNOLOGICAL REVIEWS | 2001年 / 184卷

关键词：

D O I：

10.1034/j.1600-065x.2001.1840105.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Macrophages (mphi) play a crucial role in the immune system. The rat offers unique advantages for studying the biology of mphi. Firstly, monoclonal antibodies (mAb) against many rat mphi surface glycoproteins have become available. These have not only demonstrated a considerable heterogeneity among mphi, but have also allowed the characterization of various mphi surface molecules in terms of structure, expression regulation and function. Furthermore, substantial numbers of rat mphi can be isolated from various sites (e.g. blood, peritoneal cavity, lung and other tissues), enabling proper molecular and functional analysis of these mphi populations. Finally, a number of (unique) experimental models for human diseases have been developed in the rat, making possible the evaluation of the involvement of mphi in pathogenesis. For this, a method for the selective elimination of mphi from various tissues in vivo has proven very useful. Here, we will review the contribution that the rat has made to understanding the immunobiology of mphi in particular, we will discuss the surface (glyco)proteins on rat mphi in differentiation and function, and the involvement of mphi in rat models of disease.

引用

页码：45 / 57

页数：13

共 126 条

[101] Regulation of CD163 on human macrophages:: cross-linking of CD163 induces signaling and activation [J].

Van den Heuvel, MM ;

Tensen, CP ;

van As, JH ;

Van den Berg, TK ;

Fluitsma, DM ;

Dijkstra, CD ;

Döpp, EA ;

Droste, A ;

Van Gaalen, FA ;

Sorg, C ;

Högger, P ;

Beelen, RHJ .

JOURNAL OF LEUKOCYTE BIOLOGY, 1999, 66 (05) :858-866

[102] Reactive oxygen species enhance the migration of monocytes across the blood-brain barrier in vitro [J].

van der Goes, A ;

Wouters, D ;

van der Pol, SMA ;

Huizinga, R ;

Ronken, E ;

Adamson, P ;

Greenwood, J ;

Dijkstra, CD ;

de Vries, HE .

FASEB JOURNAL, 2001, 15 (08) :1852-+

[103] Reactive oxygen species are required for the phagocytosis of myelin by macrophages [J].

van der Goes, A ;

Brouwer, J ;

Hoekstra, K ;

Roos, D ;

van den Berg, TK ;

Dijkstra, CD .

JOURNAL OF NEUROIMMUNOLOGY, 1998, 92 (1-2) :67-75

[104]

van Overdam K A, 2000, Transpl Int, V13 Suppl 1, pS504

[105]

van Rooijen N, 1992, Semin Immunol, V4, P237

[106] ROLE OF BETA-2 INTEGRINS IN THE RECRUITMENT OF PHAGOCYTIC-CELLS IN JOINT INFLAMMATION IN THE RAT [J].

VANDELANGERIJT, AGM ;

HUITINGA, I ;

JOOSTEN, LAB ;

DIJKSTRA, CD ;

VANLENT, PLEM ;

VANDENBERG, WB .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1994, 73 (01) :123-131

[107]

vandenBerg T, 1996, J IMMUNOL, V157, P3130

[108] SIALOADHESIN ON MACROPHAGES - ITS IDENTIFICATION AS A LYMPHOCYTE ADHESION MOLECULE [J].

VANDENBERG, TK ;

BREVE, JJP ;

DAMOISEAUX, JGMC ;

DOPP, EA ;

KELM, S ;

CROCKER, PR ;

DIJKSTRA, CD ;

KRAAL, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (03) :647-655

[109] Macrophage phagocytosis of myelin in vitro determined by flow cytometry: Phagocytosis is mediated by CR3 and induces production of tumor necrosis factor-alpha and nitric oxide [J].

vanderLaan, LJW ;

Ruuls, SR ;

Weber, KS ;

Lodder, IJ ;

Dopp, EA ;

Dijkstra, CD .

JOURNAL OF NEUROIMMUNOLOGY, 1996, 70 (02) :145-152

[110]

VANDERVEEN G, 1994, INVEST OPHTH VIS SCI, V35, P3505

← 4 5 6 7 8 9 10 11 12 13 →