The European opposition against the BRCA gene patents

被引：22

作者：

Matthijs, G ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

来源：

FAMILIAL CANCER | 2006年 / 5卷 / 01期

关键词：

BRCA1; BRCA2; familial breast cancer; intellectual property; licensing; patenting;

D O I：

10.1007/s10689-005-2580-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In 2001, the European Patent Organisation (EPO) granted 3 patents on the BRCA1 gene (EP-B-699754, EP-B-705903, EP-B-705902) to Myriad Genetics. The patents, and the option of the patent holder to strictly exert its monopoly right by requesting that all diagnostic testing be done at its laboratory in the United States, has evoked strong reactions in Europe. Several opposition procedures have been started against these patents. After oral hearings at the EPO in Munich in May 2004, the first patent was revoked due to errors contained in the initially filed sequence. At oral proceedings in January 2005, the other two patents were severely limited in scope. The discussion on inventive step on the cloning of the BRCA1 gene - other than the one that relates to the priority date - has not taken place. In other words, the EPO has not questioned the patentability of this gene per se. The author participated in the hearings in Munich and would like to give the genetic community a firsthand account of the case.

引用

页码：95 / 102

页数：8

共 9 条

[1] BRCA1 MUTATIONS IN PRIMARY BREAST AND OVARIAN CARCINOMAS [J].

FUTREAL, PA ;

LIU, QY ;

SHATTUCKEIDENS, D ;

COCHRAN, C ;

HARSHMAN, K ;

TAVTIGIAN, S ;

BENNETT, LM ;

HAUGENSTRANO, A ;

SWENSEN, J ;

MIKI, Y ;

EDDINGTON, K ;

MCCLURE, M ;

FRYE, C ;

WEAVERFELDHAUS, J ;

DING, W ;

GHOLAMI, Z ;

SODERKVIST, P ;

TERRY, L ;

JHANWAR, S ;

BERCHUCK, A ;

IGLEHART, JD ;

MARKS, J ;

BALLINGER, DG ;

BARRETT, JC ;

SKOLNICK, MH ;

KAMB, A ;

WISEMAN, R .

SCIENCE, 1994, 266 (5182) :120-122

[2] LINKAGE OF EARLY-ONSET FAMILIAL BREAST-CANCER TO CHROMOSOME-17Q21 [J].

HALL, JM ;

LEE, MK ;

NEWMAN, B ;

MORROW, JE ;

ANDERSON, LA ;

HUEY, B ;

KING, MC .

SCIENCE, 1990, 250 (4988) :1684-1689

[3]

Matthijs G, 2002, AM J HUM GENET, V71, P182

[4] European-wide opposition against the breast cancer gene patents [J].

Matthijs, G ;

Halley, D .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2002, 10 (12) :783-784

[5] A STRONG CANDIDATE FOR THE BREAST AND OVARIAN-CANCER SUSCEPTIBILITY GENE BRCA1 [J].

MIKI, Y ;

SWENSEN, J ;

SHATTUCKEIDENS, D ;

FUTREAL, PA ;

HARSHMAN, K ;

TAVTIGIAN, S ;

LIU, QY ;

COCHRAN, C ;

BENNETT, LM ;

DING, W ;

BELL, R ;

ROSENTHAL, J ;

HUSSEY, C ;

TRAN, T ;

MCCLURE, M ;

FRYE, C ;

HATTIER, T ;

PHELPS, R ;

HAUGENSTRANO, A ;

KATCHER, H ;

YAKUMO, K ;

GHOLAMI, Z ;

SHAFFER, D ;

STONE, S ;

BAYER, S ;

WRAY, C ;

BOGDEN, R ;

DAYANANTH, P ;

WARD, J ;

TONIN, P ;

NAROD, S ;

BRISTOW, PK ;

NORRIS, FH ;

HELVERING, L ;

MORRISON, P ;

ROSTECK, P ;

LAI, M ;

BARRETT, JC ;

LEWIS, C ;

NEUHAUSEN, S ;

CANNONALBRIGHT, L ;

GOLDGAR, D ;

WISEMAN, R ;

KAMB, A ;

SKOLNICK, MH .

SCIENCE, 1994, 266 (5182) :66-71

[6]

*NUFF COUNC BIOETH, ETH PAT DNA DISC PAP

[7] LOCALIZATION OF A BREAST-CANCER SUSCEPTIBILITY GENE, BRCA2, TO CHROMOSOME 13Q12-13 [J].

WOOSTER, R ;

NEUHAUSEN, SL ;

MANGION, J ;

QUIRK, Y ;

FORD, D ;

COLLINS, N ;

NGUYEN, K ;

SEAL, S ;

TRAN, T ;

AVERILL, D ;

FIELDS, P ;

MARSHALL, G ;

NAROD, S ;

LENOIR, GM ;

LYNCH, H ;

FEUNTEUN, J ;

DEVILEE, P ;

CORNELISSE, CJ ;

MENKO, FH ;

DALY, PA ;

ORMISTON, W ;

MCMANUS, R ;

PYE, C ;

LEWIS, CM ;

CANNONALBRIGHT, LA ;

PETO, J ;

PONDER, BAJ ;

SKOLNICK, MH ;

EASTON, DF ;

GOLDGAR, DE ;

STRATTON, MR .

SCIENCE, 1994, 265 (5181) :2088-2090

[8] IDENTIFICATION OF THE BREAST-CANCER SUSCEPTIBILITY GENE BRCA2 [J].

WOOSTER, R ;

BIGNELL, G ;

LANCASTER, J ;

SWIFT, S ;

SEAL, S ;

MANGION, J ;

COLLINS, N ;

GREGORY, S ;

GUMBS, C ;

MICKLEM, G ;

BARFOOT, R ;

HAMOUDI, R ;

PATEL, S ;

RICE, C ;

BIGGS, P ;

HASHIM, Y ;

SMITH, A ;

CONNOR, F ;

ARASON, A ;

GUDMUNDSSON, J ;

FICENEC, D ;

KELSELL, D ;

FORD, D ;

TONIN, P ;

BISHOP, DT ;

SPURR, NK ;

PONDER, BAJ ;

EELES, R ;

PETO, J ;

DEVILEE, P ;

CORNELISSE, C ;

LYNCH, H ;

NAROD, S ;

LENOIR, G ;

EGILSSON, V ;

BARKADOTTIR, RB ;

EASTON, DF ;

BENTLEY, DR ;

FUTREAL, PA ;

ASHWORTH, A ;

STRATTON, MR .

NATURE, 1995, 378 (6559) :789-792

[9]

2001, GENE PATENTING BMA D

← 1 →