Modulatory effects of Ixora coccinea flower on cyclophosphamide-induced toxicity in mice

被引：7

作者：

Latha, PG ^{[1
]}

Panikkar, KR ^{[1
]}

机构：

[1] Trop Bot Garden & Res Inst, Ethnomed & Ethnopharmacol Div, Trivandrum, Kerala 695562, India

来源：

PHYTOTHERAPY RESEARCH | 1999年 / 13卷 / 06期

关键词：

Ixora coccinea; cyclophosphamide; hepatic toxicity; chemoprotection; ursolic acid;

D O I：

10.1002/(SICI)1099-1573(199909)13:6<517::AID-PTR524>3.0.CO;2-Y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The active fraction of Ixora coccinea flowers showed chemoprotective effects on cyclophosphamide - induced toxicity by increasing the life span of treated mice, preventing body weight loss and maintaining near normal leucocyte and haemoglobin levels compared with cyclophosphamide treated controls. Decreased serum glutamate pyruvate transaminase (SGPT) and serum alkaline phosphatase (SAKP) levels in the Ixora coccinea treated groups indicated protection against hepatic toxicity. The active fraction was identified by phytochemical methods as the triterpenoid, ursolic acid. Copyright (C) 1999 John Wiley & Sons, Ltd.

引用

页码：517 / 520

页数：4

共 13 条

[1]

BERGMEYER HU, 1980, PRACTICAL CLIN BIOCH, V1, P685

[2]

BHANUMATHY P, 1986, INDIAN J EXP BIOL, V24, P767

[3] EFFECTS OF ROSEMARY EXTRACTS AND MAJOR CONSTITUENTS ON LIPID OXIDATION AND SOYBEAN LIPOXYGENASE ACTIVITY [J].

CHEN, QY ;

SHI, H ;

HO, CT .

JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1992, 69 (10) :999-1002

[4]

COHEN JL, 1970, J PHARMACOL EXP THER, V174, P206

[5]

COLVIN M, 1976, CANCER RES, V36, P1121

[6]

COLVIN M, 1982, PHARM PRINCIPLES CAN, P276

[7] SERUM ENZYMES AS INDICATORS OF CHEMICALLY-INDUCED LIVER-DAMAGE [J].

DROTMAN, RB ;

LAWHORN, GT .

DRUG AND CHEMICAL TOXICOLOGY, 1978, 1 (02) :163-171

[8]

FOLEY G. E., 1960, PROC AMER ASSOC CANCER RES, V3, P111

[9]

King E.J., 1980, PRACTICAL CLIN BIOCH, VI, P850

[10]

LATHA PG, 1998, IN PRESS CANC LETT

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