Peripheral WBC count and serum prolactin level in various seizure types and nonepileptic events

Purpose: To analyze effects of different types of seizures and nonepileptic event,, as ell as effects of seizure duration and lapse between the time of seizure and blood collection on serum prolactin level and peripheral white blood cell (WBC) count. Methods: We prospectively collected blood samples from all patients admitted to our Epilepsy Monitoring Unit at baseline and after in event. Blood samples were analyzed. and prolactin level and WBC count were determined. Statistical analyses were performed to evaluate the relation of each type of seizure. as duration. and time lapse between a Seizure and collection of blood sample to the serum prolactin level and peripheral WBC count. Results: Serum prolactin level increases above twice the el at baseline after a complex partial seizure or a generalized Peripheral WBC count is elevated above the upper limit of normal in about one third of cases after a generalized seizure. In generalized seizure, the length of a seizure is positively associated, whereas the lapse time between the seizure onset and blood drank is negatively correlated with the increase in WBC count. Thus the longer the seizure and quicker the blood draw, the higher the WBC count. Conclusions: We conclude that complex partial or generalized seizures are associated with an increase in serum prolactin level. Peripheral WBC count increases significantly after a generalized seizure and is probably transient in nature.