Aging impairs hippocampus-dependent long-term memory for object location in mice

被引：98

作者：

Wimmer, Mathieu E. ^{[1
,2
]}

Hernandez, Pepe J. ^{[2
]}

Blackwell, Jennifer ^{[2
]}

Abel, Ted ^{[2
]}

机构：

[1] Univ Penn, Neurosci Grad Grp, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

来源：

NEUROBIOLOGY OF AGING | 2012年 / 33卷 / 09期

基金：

美国国家科学基金会;

关键词：

Spatial memory; Aging; Mice; Object recognition; Hippocampus; RECOGNITION MEMORY; SPATIAL MEMORY; RATS; DEFICITS; STRESS; INACTIVATION; REVERSAL; LESIONS; CORTEX; DAMAGE;

D O I：

10.1016/j.neurobiolaging.2011.07.007

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The decline in cognitive function that accompanies normal aging has a negative impact on the quality of life of the elderly and their families. Studies in humans and rodents show that spatial navigation and other hippocampus-dependent functions are particularly vulnerable to the deleterious effects of aging. However, reduced motor activity and alterations in the stress response that accompany normal aging can hinder the ability to study certain cognitive behaviors in aged animals. In an attempt to circumvent these potential confounds, we used a hippocampus-dependent object-place recognition task to show that long-term spatial memory is impaired in aged mice. Aged animals performed similarly to young adult mice on an object recognition task that does not rely on hippocampal function. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：2220 / 2224

页数：5

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