Navigation rules for vessels and neurons: cooperative signaling between VEGF and neural guidance cues

被引:22
作者
Chauvet, Sophie [1 ]
Burk, Katja [1 ]
Mann, Fanny [1 ]
机构
[1] Aix Marseille Univ, CNRS, IBDM, UMR 7288, F-13288 Marseille 9, France
关键词
Axon guidance; Angiogenesis; VEGF; Tip cell; Growth cone; ENDOTHELIAL GROWTH-FACTOR; GRANULE CELL-MIGRATION; STIMULATES AXONAL OUTGROWTH; CENTRAL-NERVOUS-SYSTEM; VASCULAR MORPHOGENESIS; CARDIOVASCULAR DEVELOPMENT; VALVE FORMATION; OPTIC CHIASM; LYMPHATIC VASCULATURE; EXTRACELLULAR-MATRIX;
D O I
10.1007/s00018-013-1278-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Many organs, such as lungs, nerves, blood and lymphatic vessels, consist of complex networks that carry flows of information, gases, and nutrients within the body. The morphogenetic patterning that generates these organs involves the coordinated action of developmental signaling cues that guide migration of specialized cells. Precision guidance of endothelial tip cells by vascular endothelial growth factors (VEGFs) is well established, and several families of neural guidance molecules have been identified to exert guidance function in both the nervous and the vascular systems. This review discusses recent advances in VEGF research, focusing on the emerging role of neural guidance molecules as key regulators of VEGF function during vascular development and on the novel role of VEGFs in neural cell migration and nerve wiring.
引用
收藏
页码:1685 / 1703
页数:19
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