Cellular factors required for Lassa virus budding

被引：117

作者：

Urata, S

Noda, T

Kawaoka, Y

Yokosawa, H

Yasuda, J ^{[1
]}

机构：

[1] Natl Res Inst Police Sci, Dept Forens Sci 1, Kashiwa, Chiba 2770882, Japan

[2] Hokkaido Univ, Grad Sch Pharmaceut Sci, Dept Biochem, Sapporo, Hokkaido 0600812, Japan

[3] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Tokyo 1088639, Japan

[4] Univ Wisconsin, Sch Vet Med, Dept Pathol Sci, Madison, WI 53706 USA

来源：

JOURNAL OF VIROLOGY | 2006年 / 80卷 / 08期

关键词：

D O I：

10.1128/JVI.80.8.4191-4195.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

It is known that Lassa virus Z protein is sufficient for the release of virus-like particles (VLPs) and that it has two L domains, PTAP and PPPY, in its C terminus. However, little is known about the cellular factor for Lassa virus budding. We examined which cellular factors are used in Lassa virus Z budding. We demonstrated that Lassa Z protein efficiently produces VLPs and uses cellular factors, Vps4A, Vps4B, and Tsg101, in budding, suggesting that Lassa virus budding uses the multivesicular body pathway functionally. Our data may provide a clue to develop an effective antiviral strategy for Lassa virus.

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页码：4191 / 4195

页数：5

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