Mouse eye gene microarrays for investigating ocular development and disease

被引：45

作者：

Farjo, R

Yu, JD

Othman, MI

Yoshida, S

Sheth, S

Glaser, T

Baehr, W

Swaroop, A

机构：

[1] Univ Michigan, WK Kellogg Eye Ctr, Dept Ophthalmol, Ann Arbor, MI 48105 USA

[2] Univ Michigan, WK Kellogg Eye Ctr, Dept Visual Sci, Ann Arbor, MI 48105 USA

[3] Univ Utah, Hlth Sci Ctr, Eccles Inst Human Genet, Moran Eye Ctr,Dept Ophthalmol, Salt Lake City, UT 84132 USA

[4] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48105 USA

来源：

VISION RESEARCH | 2002年 / 42卷 / 04期

关键词：

expression analysis; gene profile; functional genomics; cellular pathways; retinal degeneration; mouse eye mutants;

D O I：

10.1016/S0042-6989(01)00219-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microarray technology can facilitate simultaneous expression analysis of thousands of genes and assist in delineating cellular pathways involved in development or disease pathogenesis. Since public databases and commercial cDNA microarrays have an under-representation of eye-expressed genes. we generated over 3000 expressed sequence tags from three unamplified mouse eye/retina cDNA libraries. These eye-expressed genes were used to produce cDNA microarrays. Methodology for printing of slides, hybridization, scanning and data analysis has been optimized. The I-gene microarrays will be useful for establishing expression profiles of the mouse eye/retina and provide a resource for defining molecular pathways involved in development. aging and disease. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：463 / 470

页数：8

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