Psychosis and brain volume changes during the first five years of schizophrenia

被引：78

作者：

Cahn, W. ^{[1
]}

Rais, M. ^{[1
]}

Stigter, F. P. ^{[1
]}

van Haren, N. E. M. ^{[1
]}

Caspers, E. ^{[1
]}

Pol, H. E. Hulshoff ^{[1
]}

Xu, Z. ^{[1
]}

Schnack, H. G. ^{[1
]}

Kahn, R. S. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Psychiat, Rudolf Magnus Inst Neurosci, NL-3584 CX Utrecht, Netherlands

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2009年 / 19卷 / 02期

关键词：

First-episode schizophrenia; Psychosis; Brain volumes; Longitudinal; Neuroimaging; 1ST-EPISODE SCHIZOPHRENIA; IMAGING EVIDENCE; MATTER; GRAY; MORPHOLOGY; MRI; ABNORMALITIES; INSTRUMENT; DURATION; EPISODE;

D O I：

10.1016/j.euroneuro.2008.10.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The underlying mechanisms explaining brain volume changes in schizophrenia are not yet understood, but psychosis might be related to these changes. Forty-eight patients with first-episode schizophrenia underwent Magnetic Resonance Imaging brain scanning at inclusion and after five years. An association was found between longer duration of psychosis, larger gray matter volume decrease and larger ventricular volume increase. These findings strongly suggest that psychosis contributes to brain volume reductions found in schizophrenia. (C) 2008 Elsevier B.V. and ECNP. All. rights reserved.

引用

页码：147 / 151

页数：5

共 27 条

[21] What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia [J].

Pol, Hilleke E. Hulshoff ;

Kahn, Rene S. .

SCHIZOPHRENIA BULLETIN, 2008, 34 (02) :354-366

[22] Excessive brain volume loss over time in cannabis-using first-episode schizophrenia patients [J].

Rais, Monica ;

Cahn, Wiepke ;

Van Haren, Neeltje ;

Schnack, Hugo ;

Caspers, Esther ;

Pol, Hilleke Hulshoff ;

Kahn, Rene .

AMERICAN JOURNAL OF PSYCHIATRY, 2008, 165 (04) :490-496

[23] Automated separation of gray and white matter from MR images of the human brain [J].

Schnack, HG ;

Pol, HEH ;

Baaré, WFC ;

Staal, WG ;

Viergever, MA ;

Kahn, RS .

NEUROIMAGE, 2001, 13 (01) :230-237

[24] A nonparametric method for automatic correction of intensity nonuniformity in MRI data [J].

Sled, JG ;

Zijdenbos, AP ;

Evans, AC .

IEEE TRANSACTIONS ON MEDICAL IMAGING, 1998, 17 (01) :87-97

[25] Volume reduction of the left planum temporale gray matter associated with long duration of untreated psychosis in schizophrenia: A preliminary report [J].

Takahashi, Tsutomu ;

Suzuki, Michio ;

Tanino, Ryoichiro ;

Zhou, Shi-Yu ;

Hagino, Hirofumi ;

Niu, Lisha ;

Kawasaki, Yasuhiro ;

Seto, Hikaru ;

Kurachi, Masayoshi .

PSYCHIATRY RESEARCH-NEUROIMAGING, 2007, 154 (03) :209-219

[26] Focal gray matter changes in schizophrenia across the course of the illness: A 5-year follow-up study [J].

van Haren, Neeltje E. M. ;

Pol, Hilleke E. Hulshoff ;

Schnack, Hugo G. ;

Cahn, Wiepke ;

Mandl, Rene C. W. ;

Collins, D. Louis ;

Evans, Alan C. ;

Kahn, Rene S. .

NEUROPSYCHOPHARMACOLOGY, 2007, 32 (10) :2057-2066

[27] Meta-analysis of regional brain volumes in schizophrenia [J].

Wright, IC ;

Rabe-Hesketh, S ;

Woodruff, PWR ;

David, AS ;

Murray, RM ;

Bullmore, ET .

AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (01) :16-25

← 1 2 3 →