Highly diastereoselective reduction and alkylation of (1R,2S)-trans-2-phenylcyclohexanol phenylglyoxylate and pyruvate using hindered hydrides and alkyl aluminates

被引：6

作者：

Boireau, G ^{[1
]}

Deberly, A ^{[1
]}

Loupy, A ^{[1
]}

Monteux, D ^{[1
]}

机构：

[1] Univ Paris 11, Inst Chim Mol Orsay, Lab React Select Supports, F-91405 Orsay, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(99)01415-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(1R,2S)-trans-2-Phenylcyciohexanol phenylglyoxylate and pyruvate are reduced with modest to excellent diastereoselectivities (30-99%) by reaction with bulky lithium trialkoxyaluminohydrides and alkylated with excellent diastereoselectivities (88-100%) by addition of hindered lithium alkoxytrialkylaluminates. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：6919 / 6922

页数：4

共 18 条

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