Effect of prolonged administration of transdermal estradiol on flow-mediated endothelium-dependent and endothelium-independent vasodilation in healthy postmenopausal women

被引:21
作者
Cagnacci, A
Modena, MG
Malmusi, S
Muia, N
Volpe, A
机构
[1] Univ Modena, Ist Ginecol & Ostetricia, I-41100 Modena, Italy
[2] Univ Modena, Inst Cardiol 2, I-41100 Modena, Italy
关键词
D O I
10.1016/S0002-9149(99)00300-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In 15 postmenopausal women with no cardiovascular risk factors, hormone replacement with transdermal estradiol (50 mu g/day for 2 months) did not enhance flow-mediated endothelium-dependent vasodilation, reduce endothelium-independent vasodilation, and did not modify the pulsatility index and blood flow of the brachial artery. The present data do not support a positive effect of replacement with transdermal estradiol on vessel vasodilation in healthy, postmenopausal women.
引用
收藏
页码:367 / +
页数:6
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