Effect of prolonged administration of transdermal estradiol on flow-mediated endothelium-dependent and endothelium-independent vasodilation in healthy postmenopausal women

被引：21

作者：

Cagnacci, A

Modena, MG

Malmusi, S

Muia, N

Volpe, A

机构：

[1] Univ Modena, Ist Ginecol & Ostetricia, I-41100 Modena, Italy

[2] Univ Modena, Inst Cardiol 2, I-41100 Modena, Italy

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1999年 / 84卷 / 03期

关键词：

D O I：

10.1016/S0002-9149(99)00300-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 15 postmenopausal women with no cardiovascular risk factors, hormone replacement with transdermal estradiol (50 mu g/day for 2 months) did not enhance flow-mediated endothelium-dependent vasodilation, reduce endothelium-independent vasodilation, and did not modify the pulsatility index and blood flow of the brachial artery. The present data do not support a positive effect of replacement with transdermal estradiol on vessel vasodilation in healthy, postmenopausal women.

引用

收藏

页码：367 / +

页数：6

相关论文

共 20 条

[1] Effect of conjugated estrogen on peripheral flow-mediated vasodilation in postmenopausal women [J].

Al-Khalili, F ;

Eriksson, M ;

Landgren, BM ;

Schenck-Gustafsson, K .

AMERICAN JOURNAL OF CARDIOLOGY, 1998, 82 (02) :215-218

[2] TRANSDERMAL ESTRADIOL - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC EFFICACY IN THE TREATMENT OF MENOPAUSAL COMPLAINTS [J].

BALFOUR, JA ;

HEEL, RC .

DRUGS, 1990, 40 (04) :561-582

[3]

BARRETTCONNOR E, 1996, MATURITAS, V23, P277

[4] NEGATIVE FEEDBACK-REGULATION OF ENDOTHELIAL-CELL FUNCTION BY NITRIC-OXIDE [J].

BUGA, GM ;

GRISCAVAGE, JM ;

ROGERS, NE ;

IGNARRO, LJ .

CIRCULATION RESEARCH, 1993, 73 (05) :808-812

[5] Estrogen replacement reverses endothelial dysfunction in postmenopausal women [J].

Bush, DE ;

Jones, CE ;

Bass, KM ;

Walters, GK ;

Bruza, JM ;

Ouyang, P .

AMERICAN JOURNAL OF MEDICINE, 1998, 104 (06) :552-558

[6] Vascular aspects of oestrogen [J].

Collins, P .

MATURITAS, 1996, 23 (02) :217-226

[7] Estradiol therapy combined with progesterone and endothelium-dependent vasodilation in postmenopausal women [J].

Gerhard, M ;

Walsh, BW ;

Tawakol, A ;

Haley, EA ;

Creager, SJ ;

Seely, EW ;

Ganz, P ;

Creager, MA .

CIRCULATION, 1998, 98 (12) :1158-1163

[8] ACUTE VASCULAR EFFECTS OF ESTROGEN IN POSTMENOPAUSAL WOMEN [J].

GILLIGAN, DM ;

BADAR, DM ;

PANZA, JA ;

QUYYUMI, AA ;

CANNON, RO .

CIRCULATION, 1994, 90 (02) :786-791

[9]

GISCLARD V, 1988, J PHARMACOL EXP THER, V244, P19

[10] UP-REGULATION OF NITRIC-OXIDE SYNTHASE BY ESTRADIOL IN HUMAN AORTIC ENDOTHELIAL-CELLS [J].

HISHIKAWA, K ;

NAKAKI, T ;

MARUMO, T ;

SUZUKI, H ;

KATO, R ;

SARUTA, T .

FEBS LETTERS, 1995, 360 (03) :291-293