Analysing the developing lymphocyte system of neonates and infants

被引：17

作者：

de Vries, E

de Groot, R

de Bruin-Versteeg, S

Comans-Bitter, WM

van Dongen, JJM

机构：

[1] Erasmus Univ, Dept Immunol, NL-3000 DR Rotterdam, Netherlands

[2] Univ Rotterdam Hosp, Sophia Childrens Hosp, Dept Paediat, Rotterdam, Netherlands

[3] Bosch Medictr, Dept Paediat, Shertogenbosch, Netherlands

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1999年 / 158卷 / 08期

关键词：

flow cytometry; immunophenotyping; infant; lymphocyte subsets; neonate;

D O I：

10.1007/s004310051162

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Technical developments in immunophenotyping and function testing have greatly facilitated studies on the developing lymphocyte system in the past decade and contributed to a better interpretation of the data obtained in these studies. This is important for the correct interpretation of data obtained in paediatric patients with possible immunological diseases. The age-related differences in lymphocyte subpopulations and function imply that the available adult reference values cannot be used in children. Conclusion In this review we give an outline of the technical developments, their influence upon the interpretation of data, and the available literature about age-related changes in the developing lymphocyte system.

引用

页码：611 / 617

页数：7

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