Direct catalytic enantioselective α-aminoxylation of ketones:: A stereoselective synthesis of α-hydroxy and α,α′-dihydroxy ketones

被引：226

作者：

Bogevig, A ^{[1
]}

Sundén, H ^{[1
]}

Córdova, A ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 09期

关键词：

asymmetric catalysis; ketones; oxidation; proline;

D O I：

10.1002/anie.200353018

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Proline-catalyzed reactions between unmodified ketones and nitrosobenzene proceed with excellent diastereo- and enantioselectivities to provide protected α-hydroxy and α,α′-dihydroxy ketones [Eq. (1)]. Such compounds with chiral α-hydroxy carbonyl units are crucial in natural product synthesis.

引用

页码：1109 / 1112

页数：4

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