Replication of Damaged DNA

被引：26

作者：

Lehmann, Alan R. ^{[1
]}

机构：

[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

来源：

CELL CYCLE | 2003年 / 2卷 / 04期

关键词：

DNA damage; DNA polymerase; translesion synthesis; xeroderma pigmentosum;

D O I：

10.4161/cc.2.4.407

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA damage is generated continually inside cells. In order to be able to replicate past damaged bases (translesion synthesis), the cell employs a series of specialised DNA polymerases, which singly or in combination, are able to bypass many different types of damage. The polymerases have similar structural domains to classical polymerases, but they have a more open structure to allow altered bases to fit into their active sites. Although not required for replication of undamaged DNA, some at least of these polymerases are located in replication factories. Emerging evidence suggests that the polymerase switch from replicative to translesion polymerases might be mediated by post-translational modifications.

引用

页码：300 / 302

页数：3

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