A case of hepatosplenic γ-δ T-cell lymphoma with a transient response to Fludarabine and Alemtuzumab

被引：53

作者：

Mittal, S ^{[1
]}

Milner, BJ

Johnston, PW

Culligan, DJ

机构：

[1] Aberdeen Royal Infirm, Dept Clin Haematol, Aberdeen AB25 2ZN, Scotland

[2] Univ Aberdeen, Dept Med & Therapeut, Aberdeen, Scotland

[3] Aberdeen Royal Infirm, Dept Pathol, Aberdeen AB25 2ZN, Scotland

[4] Aberdeen Royal Infirm, Dept Clin Haematol, Aberdeen AB25 2ZN, Scotland

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2006年 / 76卷 / 06期

关键词：

hepatosplenic gamma-delta T-cell lymphoma; transient response to Fludarabine and Alemtuzumab;

D O I：

10.1111/j.1600-0609.2006.00646.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatosplenic gamma-delta T-cell lymphoma is a rare, usually fatal lymphoma and available literature on management is sparse. Allografting is probably the only curative option. We describe a further case with a dramatic, though transient response to Fludarabine and Alemtuzumab combination, following a failure of conventional chemotherapy. Given the dreadful prognosis with conventional chemotherapy, it is a regimen worth pursuing as a disease reduction strategy prior to allograft where appropriate.

引用

页码：531 / 534

页数：4

共 19 条

[1] Hepatosplenic γδ T-cell lymphoma is a rare clinicopathologic entity with poor outcome:: report on a series of 21 patients [J].

Belhadj, K ;

Reyes, F ;

Farcet, JP ;

Tilly, H ;

Bastard, C ;

Angonin, R ;

Deconinck, E ;

Charlotte, F ;

Leblond, V ;

Labouyrie, E ;

Lederlin, P ;

Emile, JF ;

Delmas-Marsalet, A ;

Arnulf, B ;

Zafrani, ES ;

Gaulard, P .

BLOOD, 2003, 102 (13) :4261-4269

[2] Long-term survival with allogeneic stem cell transplant and donor lymphocyte infusion following salvage therapy with Anti-CD52 monoclonal antibody (Campath) in a patient with α/β hepatosplenic T-cell non-Hodgkin's lymphoma [J].

Chanan-Khan, A ;

Islam, T ;

Alam, A ;

Miller, KC ;

Gibbs, J ;

Barcos, M ;

Czuczman, MS ;

Paplham, P ;

Hahn, T ;

McCarthy, P .

LEUKEMIA & LYMPHOMA, 2004, 45 (08) :1673-1675

[3] Alemtuzumab in peripheral T-cell malignancies [J].

Dearden, C .

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2004, 19 (04) :391-398

[4]

FARCET JP, 1990, BLOOD, V75, P2213

[5] Hepatosplenic γδ T-cell lymphoma in a 10-year-old boy successfully treated with hematopoietic stem cell transplantation [J].

Gassas, A ;

Kirby, M ;

Weitzman, S ;

Ngan, B ;

Abla, O ;

Doyle, JJ .

AMERICAN JOURNAL OF HEMATOLOGY, 2004, 75 (02) :113-114

[6]

Gopcsa L, 2002, HAEMATOLOGIA, V32, P519

[7] 2′-deoxycoformycin for hepatosplenic γδ T-cell lymphoma [J].

Grigg, AP .

LEUKEMIA & LYMPHOMA, 2001, 42 (04) :797-799

[8] Hepatosplenic γδ T-cell lymphoma:: Complete response induced by treatment with pentostatin [J].

Iannitto, E ;

Barbera, V ;

Quintini, G ;

Cirrincione, S ;

Leone, M .

BRITISH JOURNAL OF HAEMATOLOGY, 2002, 117 (04) :995-996

[9] Post transplant CD8+γδ T-cell lymphoma associated with human herpes virus-6 infection [J].

Lin, WC ;

Moore, JO ;

Mann, KP ;

Traweek, ST ;

Smith, C .

LEUKEMIA & LYMPHOMA, 1999, 33 (3-4) :377-384

[10] Hepatosplenic T-gammadelta lymphoma in a patient with Crohn's disease treated with azathioprine [J].

Navarro, JT ;

Ribera, JM ;

Mate, JL ;

Granada, I ;

Juncà, J ;

Batlle, M ;

Millá, F ;

Feliu, E .

LEUKEMIA & LYMPHOMA, 2003, 44 (03) :531-533

← 1 2 →