Orphanin FQ reduces morphine-induced dopamine release in the nucleus accumbens: a microdialysis study in rats

被引：76

作者：

Di Giannuario, A ^{[1
]}

Pieretti, S ^{[1
]}

Catalani, A ^{[1
]}

Loizzo, A ^{[1
]}

机构：

[1] Ist Super Sanita, Farmacol Lab, I-00161 Rome, Italy

来源：

NEUROSCIENCE LETTERS | 1999年 / 272卷 / 03期

关键词：

orphanin; nociceptin; morphine; microdialysis; dopamine; nucleus accumbens;

D O I：

10.1016/S0304-3940(99)00579-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects induced by orphanin FQ (OFQ) on morphine-induced dopamine (DA), 3,4-dihydroxyphenilacetic acid (DOPAC) and homovanillic acid (HVA) release in the nucleus accumbens were studied in rats by using microdialysis with electrochemical detection. Morphine administered intraperitoneally (i.p., 2, 5 and 10 mg/kg) dose-dependently increased DA and metabolites release in the nucleus accumbens. OFQ intracerebroventricularly (i.c.v.) administered at doses of 2, 5 and 10 nmol did not change DA and metabolites release in the nucleus accumbens. OFQ (10 nmol) administered i.c.v. 15 min before morphine (5 and 10 mg/kg, i.p.) significantly reduced morphine-induced DA and metabolites release in the nucleus accumbens. These effects suggest that OFQ may regulate the stimulant action linked to morphine-induced DA release in the nucleus accumbens. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：183 / 186

页数：4

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